The synopsis for this grant opportunity is detailed below, following
this paragraph. This synopsis contains all of the updates to this
document that have been posted as of
12/15/2006
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updates have been made to the opportunity synopsis, update information
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Document Type:
Grants Notice
Funding Opportunity Number:
PA-07-175
Opportunity Category:
Discretionary
Posted Date:
Dec 15, 2006
Creation Date:
Dec 05, 2008
Original Closing Date for Applications:
Multiple Receipt Dates - See Link to Full Announcement for details.
Current Closing Date for Applications:
Multiple Receipt Dates - See Link to Full Announcement for details.
Archive Date:
Oct 02, 2009
Funding Instrument Type:
Grant
Category of Funding Activity:
Education
Food and Nutrition
Health
Category Explanation:
Expected Number of Awards:
Estimated Total Program Funding:
Award Ceiling:
Award Floor:
CFDA Number(s):
93.273
--
Alcohol Research Programs
93.393
--
Cancer Cause and Prevention Research
93.396
--
Cancer Biology Research
93.848
--
Digestive Diseases and Nutrition Research
Cost Sharing or Matching Requirement:
No
Eligible Applicants
State governments
County governments
City or township governments
Special district governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility:
Foreign institutions are eligible to apply.
Agency Name
National Institutes of Health
Description
-Purpose. The aim of this Funding Opportunity Announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. The National Institute of Alcohol Abuse and Alcoholism (NIAAA) is specifically interested in receiving applications that examine the impact(s) of chronic alcohol consumption on levels of S-adenosylmethionine (SAM), betaine, and folate, and possible associations with DNA methylation and cancer. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is particularly interested in receiving applications that address normal and neoplastic conditions focusing on the impact of epigenetics on cell division, differentiation, and/or apoptosis in the gastrointestinal (GI) tract and related organs. -Mechanism of Support. This FOA will utilize the R01 grant mechanism and runs in parallel with two FOAs of identical scientific scope PA-06-414, which solicits applications using the NIH small (R03) grant mechanism, and PA-06-413, which solicits applications using the NIH exploratory/developmental (R21) grant mechanism.
