The synopsis for this grant opportunity is detailed below, following
this paragraph. This synopsis contains all of the updates to this
document that have been posted as of
04/02/2008
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Document Type:
Grants Notice
Funding Opportunity Number:
PA-08-131
Opportunity Category:
Discretionary
Posted Date:
Apr 02, 2008
Creation Date:
Dec 05, 2008
Original Closing Date for Applications:
May 07, 2011
Current Closing Date for Applications:
May 07, 2011
Archive Date:
Jun 07, 2011
Funding Instrument Type:
Grant
Category of Funding Activity:
Education
Health
Category Explanation:
Expected Number of Awards:
Estimated Total Program Funding:
Award Ceiling:
Award Floor:
CFDA Number(s):
93.393
--
Cancer Cause and Prevention Research
93.396
--
Cancer Biology Research
Cost Sharing or Matching Requirement:
No
Eligible Applicants
State governments
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility:
Other Eligible Applicants include the following:
Eligible Agencies of the Federal Government
Faith-based or Community-based Organizations
Non-domestic (non-U.S.) Entities (Foreign Organizations)
Regional Organizations
U.S. Territory or Possession
Agency Name
National Institutes of Health
Description
-Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), is designed to stimulate research efforts aimed at establishing the physiological significance of dietary components in modulating the tumoricidal cell activity of natural killer (NK) cells for cancer prevention. The focus of research projects proposed in response to this FOA should be on defining the minimum quantity and duration of exposure to specific dietary components to modulate tumoricidal cell activity of NK cells for cancer prevention and the underlying mechanism(s) accounting for this response. Proposed projects must include animal and/or human investigations to be considered responsive to this announcement. Highly purified populations of immune cells, specific tumor cells such as RMA-S that lack class I MHC expression, target cell-free system, or single-cell assays may be used to define the molecular basis for the diet-induced changes in tumoricidal activity. However, the in vitro studies are only to be used to support in vivo studies and should not constitute the primary focus of the application. Molecular targets for food components may be examined at the sites of the tumoricidal cell receptors and cancer cell specific ligands, the output of tumoricidal cytokines (e.g., IFN-g), and the release of lytic granules such as a granulysin, perforin, and serine proteases (granzymes).
-Mechanism of Support. This FOA will utilize the NIH research project R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-08-132, that solicits applications for exploratory, pilot projects under the NIH R21 grant mechanism.
