The synopsis for this grant opportunity is detailed below, following
this paragraph. This synopsis contains all of the updates to this
document that have been posted as of
05/02/2008
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updates have been made to the opportunity synopsis, update information
is provided below the synopsis.
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Document Type:
Grants Notice
Funding Opportunity Number:
PA-08-165
Opportunity Category:
Discretionary
Posted Date:
May 02, 2008
Creation Date:
Dec 05, 2008
Original Closing Date for Applications:
May 07, 2011
Current Closing Date for Applications:
May 07, 2011
Archive Date:
Jun 07, 2011
Funding Instrument Type:
Grant
Category of Funding Activity:
Education
Health
Category Explanation:
Expected Number of Awards:
Estimated Total Program Funding:
Award Ceiling:
$200,000
Award Floor:
CFDA Number(s):
93.393
--
Cancer Cause and Prevention Research
93.394
--
Cancer Detection and Diagnosis Research
93.395
--
Cancer Treatment Research
93.396
--
Cancer Biology Research
93.399
--
Cancer Control
Cost Sharing or Matching Requirement:
No
Eligible Applicants
State governments
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Additional Information on Eligibility:
Other Eligible Applicants include the following:
Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
Agency Name
National Institutes of Health
Description
Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), and the National Institute on Aging (NIA), encourages research in all aspects of tumor stem cell biology, including the molecular and biochemical regulation of embryonic and adult stem cell behavior relevant to tumor formation. Tumor stem cells are a rare population of cells that can recapitulate all the cell types represented in the original tumor. Tumor stem cells are capable of self-renewal and asymmetric cell division. These cells are putatively responsible for the transplantability and metastatic properties of tumors. This FOA intends to stimulate efforts on isolation and characterization of tumor stem cells from a large spectrum of tumors. Such studies are important in order to understand the progression of malignant diseases. They may also inspire the development of new therapeutic strategies based on specific targeting of tumor stem cells. In addition, more research is encouraged to understand the genetic and biochemical regulatory mechanisms that control the self-renewal phenotype, asymmetric cell division, and the stem cell microenvironment (or niche ). It is anticipated that the results of such research will ultimately improve the specificity and long-term effectiveness of cancer therapy.
